Sultrim 240 – Oral Powder for Veterinary Use

Pharmacotherapeutic group: Systemic antimicrobial and antibacterial agent.

Target species: Cattle, carnivorous animals.

Composition (per 1 g of powder):

• Sulfamethoxazole – 200 mg

• Trimethoprim – 40 mg
  Excipients: Lactose

Description:
Uniform powder, white or grayish-white in color, with a characteristic specific odor.

Pharmacological properties

Sultrim 240 is a combined antimicrobial preparation whose action is based on the synergistic effect of sulfamethoxazole and trimethoprim, providing a broad-spectrum bactericidal effect against gram-positive and gram-negative microorganisms, including:
Streptococcus spp., Staphylococcus spp., Streptococcus pneumoniae, Enterococcus faecalis, Brucella spp., Chlamydia spp., Escherichia coli (including enterotoxigenic strains), Salmonella spp., Shigella spp., Pasteurella spp., Bordetella pertussis, Proteus spp., Enterobacter spp., Klebsiella spp., certain Pseudomonas species, Listeria spp., and also effective against protozoa (Plasmodium spp., Toxoplasma gondii) and some pathogenic fungi (Mycobacterium spp., Actinomyces israelii, Coccidioides immitis, Histoplasma capsulatum, Leishmania spp.).

Sulfamethoxazole acts bacteriostatically by inhibiting the utilization of para-aminobenzoic acid (PABA) in bacterial cells, thereby blocking the synthesis of dihydrofolic acid. Trimethoprim reversibly inhibits dihydrofolate reductase, an enzyme essential in folic acid metabolism, preventing the conversion of dihydrofolate to tetrahydrofolate. Together, they block the synthesis of purines and nucleic acids required for bacterial growth and reproduction.

After oral administration, both active substances are rapidly absorbed from the gastrointestinal tract and distributed to organs and tissues, reaching maximum plasma concentration in 2–3 hours and maintaining therapeutic levels for up to 24 hours. The drug is partially metabolized and excreted mainly via the kidneys (60–80% unchanged), with minor excretion through bile, saliva, and milk.

According to toxicity classification, Sultrim 240 belongs to low-hazard substances (class IV) and, when used in recommended doses, has no sensitizing, embryotoxic, teratogenic, or mutagenic effects.

Indications for use

Sultrim 240 is used to treat bacterial infectious diseases in cattle, pigs, rabbits, and poultry caused by microorganisms sensitive to the preparation. Indications include:
Respiratory tract, gastrointestinal tract, urinary and genital tract bacterial infections, secondary bacterial infections following viral diseases, skin and soft tissue infections (acne, abscesses, pyoderma, wound infections), and protozoal infections (coccidiosis).

Specifically:

• Cattle: Diarrhea, salmonellosis, pasteurellosis, pneumonia, staphylococcal abscesses, urinary tract infections, mastitis.

• Pigs: Colibacteriosis, atrophic rhinitis, salmonellosis, pasteurellosis, toxoplasmosis, haemophilus pleuropneumonia, erysipelas.

• Rabbits: Coccidiosis, salmonellosis, staphylococcosis.

• Poultry: Coccidiosis, pasteurellosis, colibacteriosis, salmonellosis, staphylococcosis, infectious rhinitis.

Dosage and administration

Administer orally mixed with feed or diluted in drinking water.

• Cattle, pigs, poultry, rabbits:

  • With water: First day – 1 g of powder per 1 L of drinking water; following 2–3 days – 0.5 g/L.

  • With feed: First day – 2 g per 1 kg of feed; following 2–3 days – 1 g/kg.

Adverse reactions

No side effects or complications are usually observed.
Dogs, cats, and pigs may exhibit hypersensitivity to sulfonamides, which can cause vomiting, loss of appetite, diarrhea, polyarthritis, or skin allergic reactions. If these occur, discontinue use immediately.

Contraindications

Do not use in animals with hypersensitivity to the active substances, during pregnancy or lactation, or in adult ruminants.
Contraindicated in animals with anemia, acute hepatitis, or severe kidney disorders (nephritis).
During prolonged use, monitor blood parameters.

Incompatibility

Do not combine with other antibiotics, coccidiostats, or drugs containing para-aminobenzoic acid or its esters (e.g., procaine, tetracaine).
Do not administer concurrently with hexamethylenetetramine (methenamine).

Withdrawal period

Slaughter for meat is permitted no earlier than 5 days after the last administration of the drug.

Packaging: 250 g plastic container.

Storage conditions: Store in a dry, dark place at temperatures below 25°C.
Shelf life: 3 years.
Manufacturer: Biotecs Ltd., Tbilisi, Georgia, Iumashvili St. #8